API Intermediates
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| Sr. no | API Name | Cas No. | Therapeutic use | Intermediate Name | Cas No. |
|---|---|---|---|---|---|
| 1 | Abeprazan | 1902954-87-3 | gastroesophageal reflux disease (GERD) and peptic ulcers | Methyl 5-(2,4-difluorophenyl)-4-methoxy-1H-pyrrole-3-carboxylate | 1902955-29-6 |
| 3-Fluorobenzenesulfonyl chloride | 701-27-9 | ||||
| 2,4-Difluoro-DL-phenylglycine | 240409-02-3 | ||||
| 2,2-Difluoroethyl acetate | 1550-44-3 | ||||
| 2 | Aprepitant | 170729-80-3 | prevent the nausea and vomiting during cancer treatment (chemotherapy) | 1-(3,5-Bis(trifluoromethyl)phenyl)ethanone | 30071-93-3 |
| 4-Fluorophenylglyoxal hydrate | 447-43-8 | ||||
| 3 | Barasertib | 722544-51-6 | treatment of Tumors, Lymphoma, Solid Tumors, Solid Tumours, and Myeloid Leukemia | 2-Amino-4-fluorobenzoic acid | 446-32-2 |
| 7-Fluoro-4-quinazolone | 16499-57-3 | ||||
| 4 | Bicalutamide | 90357-06-5 | treat stage D2 metastatic prostate cancer | 5-Amino-2-bromobenzotrifluoride | 393-36-2 |
| 4-Fluorophenyl methyl sulfone | 455-15-2 | ||||
| 5 | Avacopan | 1346623-17-3 | the adjunctive treatment of adult patients with severe active anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis | 4-Methyl-3-(trifluoromethyl)aniline | 65934-74-9 |
| 2-Fluoro-6-methylbenzoic acid | 90259-27-1 | ||||
| 6 | enavogliflozin | 1415472-28-4 | sodium-glucose cotransporter-2 (SGLT2) inhibitor | 4-bromo-7-chloro-2,3-dihydrobenzofuran-6-carboxylic acid | 2411550-55-3 |
| 4-Bromo-7-chloro-6-(4-cyclopropylbenzyl)-2,3-dihydrobenzofuran | 1415477-23-4 | ||||
| 3-Chloro-2-nitrobenzoic Acid | 4771-47-5 | ||||
| 5-Bromo-2-chlorobenzoic Acid | 21739-92-4 | ||||
| Methyl 5-bromo-2-chloro-3-methoxybenzoate | 697762-67-7 | ||||
| 7 | Atogepant | 1374248-81-3 | prevent migraine attacks by blocking the calcitonin gene-related peptide (CGRP) receptor | tert-butyl ((5S,6R)-6-methyl-2-oxo-5-(2,3,6-trifluorophenyl)piperidin-3-yl)carbamate | 1456803-42-01 |
| 1-(tert-Butyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one | 1455358-06-1 | ||||
| 8 | Cetirizine | 83881-51-0 | relieve sneezing; runny nose; itchy, red, watery eyes; and itchy nose or throat due to allergies | 4-Chlorobenzophenone | 3516-95-8 |
| 4-chlorobenzhydrol | 119-56-2 | ||||
| 4-chlorobenzhydrylpiperazine | 303-26-4 | ||||
| 9 | Quetiapine Fumarate | 111974-72-2 | treat bipolar disorder (depressive and manic episodes) and schizophrenia | Dibenzo(b,f)(1,4)thiazepin-11(1OH)-one | 30690-43-8 |
| 11-Piperazinodibenzo(b,f)(1,4)thiazepine-dihydro | 111974-74-4 | ||||
| 10 | Dapagliflozine | 461432-26-8 | Type 2 Diabetes | 5-Bromo-2-chlorobenzoic acid | 21739-92-4 |
| 5-bromo-2-chloro-4’-ethoxydiphenylmethane | 461432-23-5 | ||||
| 5-bromo-2-chloro-4’-ethoxybenzophenone | 461432-22-4 | ||||
| Phenetole (Ethoxybenzene) | 103-73-1 | ||||
| 11 | Propafenone | 54063-53-5 | to prevent irregular heartbeats such as atrial fibrillation (AF) from occurring again in patients who do not have structural heart disease | 2′-hydroxy-3-phenyl-Propiophenone | 3516-95-8 |
| 2’-hydroxyacetophenone | 118-93-4 | ||||
| 4-Hydroxychalcone | 20426-12-4 | ||||
| 12 | Chlorthalidone | 77-36-1 | treats high blood pressure | 3-chlorosulfonyl-4-chlorobenzoylbenzoic acid | 68592-12-1 |
| 13 | Clomiphene Citrate | 50-41-9 | induce ovulation (egg production) in women who do not produce ova (eggs) but wish to become pregnant (infertility). | 4-Hydroxybenzophenone | 1137-42-4 |
| 14 | Dapsone | 80-08-0 | to treat leprosy (Hansen's disease) and to help control dermatitis herpetiformis, a skin problem. | 4,4′-Diaminodiphenyl Sulfone | 80-08-0 |
| 15 | Fluoxetine | 54910-89-3 | to treat major depressive disorder, bulimia, OCD, premenstrual dysphoric disorder, panic disorder, and bipolar I | N,O-dimethylhydroxylamine hydrochloride | 6638-79-5 |
| 16 | Fenofibrate & Choline Fenofibrate | 49562-28-9 856676-23-8 | to treat high levels of triglycerides and "bad" LDL cholesterol, and high levels of "good" HDL cholesterol, which are known as dyslipidaemia or hyperlipidaemia. | 4-Chloro-4′-hydroxybenzophenone | 42019-78-3 |
| Fenofibric Acid | 42017-89-0 | ||||
| 17 | Novocain | 59-46-1 | primarily as a local anesthetic for dental and minor surgical procedures, and for local or regional nerve blocks | 4-Aminobenzoic acid (PABA) | 150-13-0 |
| 18 | Haloperidol | 52-86-8 | o manage the positive symptoms of schizophrenia, including hallucinations and delusions. | 4-Chloro-4′-fluorobutyrophenone | 3874-54-2 |
| 19 | Hydroxyzine | 68-88-2 | treatment of itchiness, anxiety, insomnia, and nausea | Diphenylmethane | 101-81-5 |
| 20 | Levocetirizine | 130018-77-8 | to relieve runny nose; sneezing; and redness, itching, and tearing of the eyes caused by allergies. | Para-Chlorobenzhydryl Chloride | 134-83-8 |
| 21 | Nifurtimox | 23256-30-6 | to treat Chagas disease (an infection caused by a parasite) in children from birth to 18 years old who weigh at least 5.5 pounds (2.5 kg). | 1-Iodo-4-nitrobenzene | 636-98-6 |
| 22 | Pregabalin | 148553-50-8 | for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, fibromyalgia, neuropathic pain associated with spinal cord injury | (±)-3-Carbamoylmethyl-5-methylhexanoic acid | 181289-15-6 |
| (R)-(-)-3-Carbamoymethyl-5-methylhexanoic acid | 181289-15-6 | ||||
| 23 | Ruxolitinib | 941678-49-5 | to treat certain blood cancers like myelofibrosis and polycythemia vera, as well as steroid-refractory acute graft-versus-host disease (GVHD) | 4,6-Dihydroxypyrimidine | 1193-24-4 |
| 24 | Sertraline hydrochloride | 79559-97-0 | administered orally as the hydrochloride salt as an antidepressant for the treatment of depression, obsessive-compulsive disorder, panic disorder and post-traumatic stress disorder | 3,4-Dichlorobenzophenone | 6284-79-3 |
| 4-(3,4-dichlorophenyl)-3,4-dihydronapthalene-1(2H)-one | 79560-19-3 | ||||
| 25 | Sitafloxacin | 127254-12-0 | against a wide range of Gram-positive and -negative bacterial infections | 4-Phenoxybenzoic acid | 2215-77-2 |
| 4’-bromoacetophenone | 99-90-1 | ||||
| 26 | Terbinafine | 91161-71-6 | treat dermatophyte infections of toenails and fingernails as well as other fungal skin infections. | 1-Chloromethyl Naphthalene | 86-52-2 |
| 27 | Alpelisib | 1217486-61-7 | Breast cancer that is hormone receptor positive and HER2 negative and has a mutation in the PIK3CA gene | 3,3,3-Trifluoro-2,2-dimethylpropanoic acid | 889940-13-0 |
| 2-(1,1,1-Trifluoro-2-methylpropan-2-yl)pyridin-4(1H)-one | 1357476-66-4 | ||||
| 4-Bromo-2-(2,2,2-trifluoro-1,1-dimethylethyl)pyridine | 1357476-67-5 | ||||
| 28 | apalutamide | 956104-40-8 | metastatic castration-sensitive prostate cancer | 3-(Trifluoromethyl)-2-pyridone | 2245-83-6 |
| 5-Nitro-3-(trifluoromethyl)pyridin-2-ol | 99368-66-8 | ||||
| 2-Bromo-5-nitro-3-(trifluoromethyl)pyridine | 956104-42-0 | ||||
| 29 | daprodustat | 960539-70-2 | treat anemia caused by chronic kidney disease (CKD) in adults who have been on dialysis for at least four months | 1,3-Dicyclohexylurea | 2387-23-7 |
| 1,3-Dicyclohexylbarbituric Acid | 35824-91-0 | ||||
| N,N'-Dicyclohexylcarbodiimide | 538-75-0 | ||||
| 30 | Dabrafenib | 1195765-45-7 | to treat unresectable or metastatic melanoma, non-small cell lung cancer (NSCLC), anaplastic thyroid cancer, and other solid tumors in patients whose tumors have a specific BRAF V600 mutation | methyl 3-amino-2-fluorobenzoate | 1195768-18-3 |
| 3-Bromo-2-fluorobenzoic acid | 161957-56-8 | ||||
| 2,6-Difluorobenzenesulfonyl | 60230-36-6 | ||||
| 31 | difamilast | 937782-05-3 | topical treatment of atopic dermatitis (AD), a chronic inflammatory skin condition | 4-(Difluoromethoxy)-3-hydroxybenzaldehyde | 151103-08-1 |
| 4-(Difluoromethoxy)-3-isopropoxybenzoic acid | 159783-48-9 | ||||
| 4-(difluoromethoxy)-3-isopropoxybenzamide | 1574285-91-8 | ||||
| 32 | lazertinib | 1903008-80-9 | treatment for a certain type of non-small cell lung cancer (NSCLC) that has spread to nearby tissues or to other parts of the body | 4-Fluoro-2-methoxy-5-nitroaniline | 1075705-01-9 |
| 2-Methoxy-4-(4-morpholinyl)-5-nitrobenzenamine | 1903010-18-3 | ||||
| 33 | abemaciclib | 1231929-97-7 | targeted therapy for certain types of HR-positive, HER2-negative breast cancer, used in combination with endocrine therapy for early-stage, high-risk breast cancer | 4-Bromo-2,6-difluoroaniline | 67567-26-4 |
| 34 | Asundexian | 2064121-65-7 | treating thromboembolic disorders by preventing clots while potentially lowering the risk of bleeding compared to direct oral anticoagulants (DOACs) | tert-Butyl 2-fluoro-4-nitrobenzoate | 157665-46-8 |
| 1-(2-Bromo-4-chlorophenyl)-4-(trifluoromethyl)-1H-1,2,3-triazole | 1445866-55-6 | ||||
| 4-Amino-2-fluorobenzamide | 609783-45-1 |